Criminal procedure 1 Assignment Example | Topics and Well Written Essays - 500 words

Criminal procedure 1 - Assignment Example e certain aspects of life, such as the abolition of segregation and definition of sexual harassment, which was brought before the supreme court for a final, legal decision. Since the courts cannot issue a legal opinion until it is officially requested, it is understandable why they did not implement the Bill of Rights until the 1960s, when it officially came into play for political and judicial changes ( â€Å"The Bill of Rights: A Brief History†). Source: American Civil Liberties Union. (n.d.). The bill of rights: A brief history. Retrieved from https://www.aclu.org/racial-justice_prisoners-rights_drug-law-reform_immigrants- rights/bill-rights-brief-history 2. In Dred Scott v. Sanford, the issue of American citizenship came into question for African- Americans. The issue was that African-Americans, whether in slavery or free were not to be considered American citizens and therefore, had not right to sue in the federal courts and that the federal government had no right to regulate slavery. The suit was brought forth by Dred Scott whose owners had brought him across territories where he was considered a free man in some states and tried to sue in order to gain his freedom. The supreme court protected the rights of the slave owners, deciding that Scott did not have the right to sue for his freedom. This landmark case is remembered for being only the second time that the courts did not uphold an Act of Congress. 3. The 14th amendement guaranteed citizenship to the United States for any person who was born or naturalized in the United States. Had this law been passed prior to Dredd v. Scott, Dredd would have seen his citizenship as an American recognized by the courts, which would then have ensure his rights as an American citizen, quite possibly gaining him his freedom in the process. It is important to remember that the courts can only act upon legal issues regarding constitutional matters once it is brought to their attention. The Dredd v. Scott case no doubt

Privatization of State Owned Enterprises Research Proposal

Privatization of State Owned Enterprises - Research Proposal Example Governments in developed countries (e.g. Britain and Japan) started privatizing SOEs in the early 1980s; by the late 1980s it had become apparent that a privatization revolution would sweep the world (Young, 1987). While the bulk of privatizations during the past decade occurred in developed countries, in recent years the emphasis has shifted to developing countries (The Economist, 1993). In these countries, capital markets can hardly absorb the large amounts of privatized equity, and governments are offering to sell SOEs to western multinationals as strategic owners (The Economist, 1993; Ramamurti, 1992). In addition, these countries look to western multinational enterprises for managerial and technical know-how. This trend creates possibilities for growth and entry into countries whose economies are currently expanding faster than most developed economies. While privatization in the 1980s created opportunities for portfolio investments, the 1990s also promise the control of privati zed firms through mergers and acquisitions (Freudenberg and Bird, 1991; Nankani, 1990; Ramamurti, 1992). For these reasons, privatization is considered here to be an international management concern. Empirical research and theory on direct investment into former SOEs, unfortunately, is scant. Economists generally agree that reducing government ownership of companies improves the macro-performance of an economy, and they also expect that a competitive environment and market discipline should increase the efficiency of the privatized firm (Donahue, 1989; Hutchinson, 1991; Ramamurti, 1992; Vickers and Yarrow, 1988). Empirical research on this latter point, however, has yielded conflicting results (Cook and Kirkpatrick, 1988; Hutchinson, 1991; Parker and Hartley, 1991). Strategic management research considering the performance of the SOE after it is acquired by a private firm is missing entirely. No mergers and acquisitions work has yet considered the purchase of SOEs, nor have researchers examined the conceptual relationship between traditional mergers and the acquisition of an enterprise from the government. On the one hand, the public/private shift inherent in privatization might imply that acquisition processes work differently for privately and publicly owned firms. The strategy, structure, and culture of the public organization can be expected to differ significantly from those of private firms because of the often special missions of SOEs and distinct environments in which they may be operating (Aharoni, 1986). Since post-acquisition integration processes are determined by the historic conditions of the merging firms (Nahavandi and Malekzadeh, 1988; Shrivastava, 1986), these differences may crucially influence the success of a merger between a private firm and a newly privatized SOE. The pre-acquisition conditions of the target also influence performance (Datta et al., 1992), and thus the distinctive contingencies of the SOE can be expected to affect post-acquisition performance as well. Furthermore, the objectives of a government selling an SOE are as much political -- that is, cat ering to specific stakeholder groups, for instance current employees of the SOE -- as economic, a fact that should significantly affect the negotiations and may also determine the post-privatization performance of the former SOE. Only recently has the strategic management literature begun to examine the implications of government policy for

Organizational behavior Term Paper Example | Topics and Well Written Essays - 3750 words

Organizational behavior - Term Paper Example There are many factors that negatively affect the solidarity of the organizational behavior and most important of those factors are discussed in this paper while taking into consideration a Wal-Mart supercentre located in Ontario, Canada. The reasons of the success of the worldwide conglomerate like Wal-Mart are also illuminated. The factors that contribute to pandemonium in an organizational setup and that tarnish the organizational behavior and culture are identified and discussed in the paper. High absenteeism and poor motivation are distinguished as the most lethal factors that weaken the strength of organizational behavior. Various strategies are also presented that can play a major role in culmination of the poisonous factors like discrimination and reduced teamwork in an organization. This is the general consensus among employing organizations that motivating racial and gender diversity in workplaces has always been the ultimate need of the time. The more chances of diversity of cultures, races and religions in a workplace, the higher would be the rate of healthy competition among the employees. Promoting diversity is the key to improve the overall productivity owing to the positive aura built through zero discrimination. 2. Introduction: Organizational behavior involves the study of all the people working together at different levels in an organization for achieving common goals. It focuses on the individual behaviors of the members of an organization and analyzes how each of them perceives the concept of organizational culture and whether they share a common thinking approach for achieving any important target. It is an unambiguous fact that even healthy conflicts in an organizational context, which are not fraught with any ill intentions, can swiftly take a negative turn if those working in an organization start taking any critical comment as personal offence. Rotten biases and ill prejudices that are among the basic factors for polluting an organizat ion’s environment, originate from negative organizational behavior and for this purpose, deep analysis of the organizational behavior by some reputable organizational consultant from time to time is highly important. Economic crisis can result if the behaviors and creativities of the members working in an organization are channeled into individual modes rather than being channeled into a mode of common welfare for that organization. This paper lays stress on the deep understanding of organizational behavior and supports this fact by taking example of Wal-Mart discount superstores in Canada. Different aspects of Wal-Mart supercentres are discussed in this paper including their structure, culture, mission, and objectives. Conflicts in any organization can create immediate chaos if mixed with discrimination and bias, and such negative emotions demand the attention of organizational consultant, who assess the reasons of conflicts and negative organizational behavior. 3. Why Wal-M art is so successful all over the globe? Wal-Mart is basically an American multinational corporation that successfully runs hains of large departmental stores all over the globe. Sam Walton founded Wal-Mart and it was under his remarkable ruling that this small corporation changed into a worldwide conglomerate in the span of a few years. The unparallel success of Wal-Mart can be judged from the fact that it was considered to be the world’

New 3 Questions on Politics and Administration Essay

New 3 Questions on Politics and Administration - Essay Example It has however been showcasing itself as one that checks over separation of powers. An issue that seemed to bring some controversy to this issue was the court’s rejection of Bush’s administration to detail prisoners of war. This led to the argument that the court would have been arguing in such a case due to lack of competency in the issues apprehended. According to Harriger (2011) and the concept of separation of powers, the court has acted in a manner to indicate that it is really enforcing for the power separation. Looking at these trends, in accordance to Harriger (2011), this separation of powers and the push by the Supreme Court trends to some judicial activism in the cases of power separation. He as well contended to the fact that he court seemed more oriented towards separation of powers than judicial supremacy. There is a bit of ignorance on the fact that judicial supremacy and defending its supremacy would be a better explanation of the activism of the court H arriger (2011). According to this author, the power war is between the congress and the federal government as well as the state governments. Harriger (2011) terms the behaviour of the courts in this case as a model of judicial activism in the sense that they do so against some constitutional values. Separation of powers is then argued to be more centralised towards public affairs in the recent past than it was thirty years ago. The issue of federalism and separation of powers comes in if the party controlling the houses differ from the President’s party. Divided governments have historically been used to show the various historical attributes that determine the struggle between the executive branches of the government. In the argument of the federalism about this struggle, there is an argument that all the government arms should be in such a manner that they can defend their own rights against invasion from the other arms. In this regard, they argue of the issues within the c onstitution that should better be served politically than in the courts Harriger (2011). Arguing on a federalist view, the constructions found in the constitution are not permanent and can be constitutionally solved. Looking at these arguments, it is evident that issues of separation of powers are directly connected to political battles in various arenas. Such issues are what led to the executive power showcased Bush as the Congress backed him up for the war on terror, considering that the houses were both controlled by republicans Harriger (2011). 2. Presidential powers According to Neustadt (1960) presidential powers are about the influence of the president to the country. The current American Presidency is a vital organ in the country’s progress and elections are taken very seriously. The current modern US President faces aid and service demands from quite some sources; the executive, congress, partisans, citizens and other countries. All these five organs are distinguishe d by what hey require of the president making this a role of the president Neustadt (1960). The obligations of the president are cut out for him alone. The President has such an importance status in the government such that there is always being demanded of his services. In his article, Neustadt (1960) states that these powers are in most cases behind the knowledge of the common man and thus will always remain at the mercy of the President. If compared to historical Presidents, the modern Presidency cannot much as the erstwhile

National Air Sapce Essay Example | Topics and Well Written Essays - 250 words

National Air Sapce - Essay Example Such a responsibility is likely to generate competitive advantage. In addition, Greenberg, McKone-Sweet, & Wilson (150) explain that premium customers are likely to offset social cost of service delivery and this will manage cost implications of the orders on the airline companies. The identified fuel efficiency will also reduce cost in the long term and increase long-term profitability. Legal obligations and consequences of breach of contract will also motivate the airline companies to uphold the orders and two possible remedies to breach of contract explain this. The companies will still be forced to make the purchases under the doctrine of specific performance and this will mean wasted time and money in judicial processes. Cancelling the contracts will also lead to monetary expenses in damages should the companies be allowed to cancel the contracts but this would still be costly (Schaffer, Agusti, & Dhooge 108). Upholding contracts for the new aircrafts offers advantages such as competitive advantage due to social responsibility, increased profitability due to fuel efficiency, and ability to raise prices among premium customers without reducing utility. Cancelling the contracts would however have legal implications into unnecessary financial losses. The companies will therefore go ahead with the contracts because of the many advantages of the move and disadvantages of cancelling the contracts. These motivate purchase of the new fuel-efficient aircrafts. Greenberg, Danna, McKone-Sweet, Kate, & Wilson, James. The new entrepreneurial leader: Ddeveloping leaders who shape social and economic opportunity. San Francisco, CA: Berrett-Koehler Publishers, 2011.

Collective empowerment Essay Example for Free

Collective empowerment Essay â€Å"To find out about my life. The truth. In the end. That’s all. † Nadine Gordimer’s 11th novel heroine, Vera Stark, takes over the hearts of literary critiques as she goes through the course of transition taking place in post-apartheid South Africa and in herself. â€Å"None to accompany me† is yet another Nadine Gordimer literary masterpiece that explores the dramatic effect of a country to an individual’s change on a personal level. The novel opens with Vera’s infidelity to her first husband; and as the story advances and she ages, she assesses her life and gains a new perspective on her relationship with her second husband, Bennett. Meanwhile, she tries to understand her daughter’s case on being a lesbian and why her husband pretends not to notice. Here, we see her struggle with her private feelings while engaged in civic issues where she had difficulty dealing with â€Å"relationships for which there was no preexisting formula of hostility or friendship, suspicion or trust. Note that the novel takes place in post-apartheid South Africa there’s been a radical change in social boundaries therefore, making it difficult to contend black interests. As Gordimer says, â€Å"When a railway line is abandoned, the tracks arent taken up. ; the railway referring to prejudiced white South Africans. Put in simpler terms, changing the law is one thing but changing the people’s attitude is another. Being a wife and a mother, a political activist and a lover, Stark’s sensible and sensual character reflects the author’s to some degree. Even her course of life takes resemblance to Gordimer’s: Vera Stark, a graduate of legal studies, becomes head of a Legal Institution established as a â€Å"reaction against the blackness of the black community, fights back the system with its own tricks. She will become the living example of how the collapse of an old regime allows us perhaps to abandon our old self. Maybe abandon an old personal life, too. Indeed, she will gradually see everything around her changing radically, and as consequences provoke other consequences, she will almost lose her life, after a murder attempt against her which will bring her face to face with the face of death, she will experience the fall of the frenzied racism monster as well as the transition towards a new regime with new supporters, ready like the others before them to be corrupted, the unjustified violence and the extreme poverty, she will revaluate her own existence, as a mother, as a companion and as a woman, she will watch her friends changing, she will be fascinated by the leader of the Black People and she will endure all these hardships with the stoicism of wisdom† (Nadine Gordimer on Vera Stark, â€Å"None to accompany me†); Likewise, Gordimer holds record for being a political activist throughout her lifetime and joined, as well as led, several organizations both legal and illegal that expressed her concerns on moral and r acial issues, especially the apartheid in South Africa. Meanwhile, the novel’s secondary characters put an intriguing twist to the story, somehow blending in whilst telling a story of their own: Veras second husband Bennet, a supposed sculptor downgraded to selling prestige luggage to provide for her; their son Ivan, a London banker, and their lesbian daughter, Annie, a South African doctor; Didymus and his wife Sibongile (Sally) Maqoma, Vera’s black friends who returned from exile after the apartheid; their lovely daughter Mpho, half-Zulu, half-Xhosa, whose been raised in London; Veras co-worker Oupa, former prisoner on Robber Island, who has big hopes and plans for South Africa; and Zeph Rapulana, one of the new black men with the skills and personal power to help makes such dreams come true. Gordimer’s portrayal of each minor character’s image was brief but delightfully vivid. Also, despite being the lead character in the novel, two lives are actually examined throughout besides Stark’s, thereâ€℠¢s Sally Maqona. After returning to South Africa from exile, she and her husband were received as heroes, for being part of the principal revolutionaries during the apartheid. However, an unexpected exchange in roles between the couple happened: Didymus, the male, was set aside the big picture for being a traditionalist whereas Sibongile, his wife, was selected to join high-profile politicians as she was regarded as one of the intellects and the most suitable to represent the new South Africa. Gordimer smoothly showed how these separate lives worked out how both women and their husbands are involved in taking down the apartheid system, and at the same time, how they handled more personal issues: a teen daughter’s pregnancy, the death of a co-worker, a son’s divorce, their own marital commitment, new employment and shifting friendships. All these are set in a growing complex political entity wherein each individual must somehow fit or adjust their identity. â€Å"Is there ever a really fair division of labour, as you call it, between couples? Vera’s daughter, Annie, asks her. Perhaps the answer to this question lies in the novel itself but then again, it’s uncertain will it be a yes or a no? Traditionally, so to speak, men take over positions dominating women. In this case however, one might find it amusing that it is the females holding the so-called ‘superior’ position instead of her husband, Sally is voted to preside over the board and even Vera has taken a seat amongst high-ranking officials. Moreover, I find it noteworthy to mention Vera’s alacritous acceptance of her daughter’s homosexuality at one part, she defends the merits of the male genitalia to her newly announced lesbian daughter. With such circumstances at hand, one wonders whether this novel was written to be intentionally inclined to feministic views or it’s just how it was meant to go. Nonetheless, this has nothing to do with Gordimer; in point of fact, she’s against sexism, racism, and the like as evident from her reactions in real life encounters. As to the novel’s setting, Gordimer’s ardent description of the South African post-apartheid is written in such a way as if meant to bring the reader inside the story itself. She highlights South Africa’s torment from racial discrimination and social division a glimpse of its ‘heterotopia’. Through Gordimer, one can not only see the narrative illustration presented but feel it, too, through the characters. It’s even more intense than reading a newspaper headliner, so to say. There’s no wonder Gordimer was able to come up with an excellent novel: she has ever since been a political activist in South Africa, expressing her thoughts through outstanding literary pieces concerning relevant issues facing the locals, and even being active in the anti-apartheid movement she joined the African National Congress during the days when it was still illegal. Her works dealt greatly with political issues, especially those of her own country, and love entwined with the lives of ordinary people. She’s won various awards through the decades including the 1991 Nobel Prize for Literature because her contribution is, in the words of Alfred Nobel, â€Å"of very great benefit to humanity†. All of her works are based from her own personal record, being one articulate witness of the contemporary world her country’s in, with a hinge of imagination reality and fiction combined. With â€Å"None to accompany me†, Nadine Gordimer certainly outdid herself this time a recollection of her previous notable works combined with a near-perfect replica of her own private life and personal beliefs on the inadequate development of her country: analphabetism and semi-alphabetism, poverty, racism, and the transition from the racist regime to the democratic state among others. Further additional concepts she used cover spatial control as a mark of repression and as an emphasis of political resistance, and a vague reference on South African urbanization. This particular flair of hers is quite remarkable, Gordimer is one of the few capable of delivering a composition where realpolitik meets the inner self it’s complex, intense, intriguing, and definitely fascinating. Regardless of recent reviews saying that her style of unfolding the narrative is more urgent compared to her earlier pieces, they commend her for keeping the ‘magic’ still. Her narrative form is unique to her she does it with sophistication and boldness; she writes what is there and she writes it with utmost comprehension and solemnity. Down to the last word, this read will leave you in awe. â€Å"It is not enough for someone to say that he is a writer. He must do what he can! †, so she says. The new South Africa that is evolving right now is coming to terms with the various repressions and discriminations it did in the past. South Africa is now freeing itself from the vestiges of apartheid and at the same time unmasking apartheid as it takes in different forms not only in society but in the hearts of its citizens. While apartheid is now officially denounced, there are still traces of it in many of its structures and apartheid still exists in the internal structures of culture and individual consciousness. One must be able to weed out apartheid inside one’s own heart even if the mind says you have already rid of it conceptually. There are practices and bad habits that are hard to break. Apartheid still exists in subliminal forms. The true affirmation and sense of self worth still needs to be developed. Collective empowerment still needs to be done on the structural level. This means poverty eradication, women empowerment, literacy programs, and economic programs that would provide labor and a genuine sense of self worth. In the area of economics, there should be access to opportunity and privilege not only for the white and the rich but also for the majority poor and the black. In the political level, the voice of the majority still needs to be heard and well represented. In the area of culture, there still needs to be a radical break from the past and a birth of a totally new culture that would define South Africa on a new level of its accomplishments and not its sins from the past.

Importance of Natural Product Synthesis

Importance of Natural Product Synthesis History of medicine dates back practically to the existence of human civilization. Historically, the majority of new drugs have been generated from natural products and from compounds derived from natural products. Natural products, including plants, animals and minerals have always been a source of therapeutic agents for many years. Natural products sometimes exhibit pharmacological or biological property that can be of therapeutic benefit in treating diseases. As such, natural products are the active components not only of most  traditional medicines  but also of many newer medications. Furthermore, synthetic analogs of natural products with improved potency and safety can be prepared and therefore natural products are often used as Lead Copmpounds for  drug discovery. In fact, natural products are the inspiration for approximately one half of U.S. Food and Drug Administration-approved drugs. The birth of the natural product synthesis dates back to 1828 when Friedrich Wà ¶hler synthesized urea, a naturally occurring substance from ammonium cyanate. This event as trivial as it may seem by today’s standards not only gave birth to a boundless science called organic synthesis but also contributed to a demystification of mother Nature by burying the fact that synthesis of nature’s molecules is her exclusive domain. The second major achievement in the field of organic synthesis is the synthesis of acetic acid from elemental carbon by Kolbe3 in 1845. It is historically significant because Kolbe coined the word Synthesis for the first time to describe the process of assembling a chemical compound from other substances. The total synthesis of naturally occurring pigments alizarin in 1869 by Graebe and Liebermann and indigo in 1878 by Baeyer represent landmark accomplishments in the field. Probably, after urea, the most spectacular total synthesis of the nineteenth c entury was that of Emil Fischer’s (†¡)-glucose not only for the complexity of the target but also for the considerable stereochemical control that accompanied it. Figure 1: Although the precedent was set in the nineteenth century, it was only in the twentieth century the field of total synthesis started to flourish when Robert Burns Woodward synthesized Quinine. This event ushered in the modern era of total synthesis and Woodward who received the 1965 Nobel Prize for Chemistry for several brilliant examples of total synthesis such as his 1954 synthesis of strychnine, cholesterol5 is regarded as the father of modern organic synthesis. Figure 2: Today the art of organic synthesis has improved to astoundingly high levels of sophistication. Through its practice, chemists are able to synthesize organic molecules of all types of structural motifs and for all intents and purposes. Some modern classical examples of total synthesis include the synthesis of prostaglandin PG2ÃŽ ± and Ginkgolide by E. J Corey, Ingenol by Wood, Brevetoxin by Nicolaou, Vancomycin by Evans, Taxol by Holton6, Nicolaou7, Wender and Danishefsky8 groups independently. The discipline of natural product synthesis today, is an important field of investigation whose dividends stretch from new scientific knowledge to practical applications. Considered by many as the flagship of organic synthesis, natural product synthesis symbolizes the power of chemical synthesis at any given time and defines its scope and limitations. It also serves to improve chemical synthesis by attempting to push its frontiers into higher molecular complexity, diversity, and efficiency. they can synthesize not only the molecules of nature and their analogues, but also myriad other organic molecules for potential applications in many areas of science, technology and everyday life Introduction to THF-containing natural products Tetrahydrofuran (THF)-containing natural products widely occur in several important families of biologically active compounds, such as the annonaceous acetogenins [1] and polyether antibiotics isolated from Streptomyces organisms (ionomycin, lonomycins A–C, or monensin) [2]. It’s worthwhile at this juncture to discuss few THF ring containing natural products such as which have been of paramount importance to the mankind and also to the researchers who have been actively involved in the synthesis and isolation of these natural products. Acetogenins Acetogenins abbreviated as AAGs are a group of THF-Containing natural products isolated from Annonacae species which are vastly distributed in tropical and subtropical regions. They exhibit different biological activities such as antitumor, ant-imalarial, anti microbial, anti protozoal, pesticidal activities2. The common structural features of acetogenins include several free hydroxy groups with various stereo centers, differently located oxygenated functional groups and tetrahydrofuran (THF) ring(s) along the long hydrocarbon chain with an ÃŽ ±, ÃŽ ²-unsaturated ÃŽ ´-lactone moiety at the end. Uvaricin, a bis THF acetogenin was the first of the AAGs isolated from Uvaria acuminata in 1982. It exhibited potent anti-cancer activity by inhibiting NADH cells in the mitochondrion. The total synthesis of Hexepi-Uvaricin was published by Hoye in 1994 and subsequently first total synthesis was achieved by Keinan in 1998. Montanacin D is a non classical acetogenin isolated from the ethanolic extract of the leaves of Annona Montana16 by Qin group in 1999, possessing a 4,8-cis THP ring along with a 16,19-trans THF ring. Ionomycin Amphidinolides Amphidinolides constitute a series of unique cytotoxic polyketide macrolides obtained from marine symbiotic dinoflagellates of the genus Amphidinium, which are symbionts of Okinawan marine flatworms Amphiscolops spp.1 They exhibit potent cytotoxic activity against murine lymphoma L1210 cells and human epidermoid carcinoma KB cells. Given below are some important Amphidinolides that incorporate a THF-ring in their structure Pectenotoxins Pectenotoxin (PTX)-group toxins are a group of polyether macrolide compounds found in microalgae and bivalve molluscs of Australia, Japan, New Zealand and some parts of Europe. Their presence in shellfish was discovered due to their high acute toxicity in the mouse bioassay after intraperitoneal (i.p.) injections of lipophilic extracts of shellfish. Pectinotoxins are exclusively produced by Dinophysis species. In shellfish they are always accompanied by closely related okadaic acid (OA)-group toxins. The common structural features of (PTX)-group toxins include a spiroketal group, three THF-rings, a bicyclic ketal and a six-membered cyclic hemiketal (Allingham et al., 2007). PTX2 is beleived to be the main precursor, from which many PTX-group toxins are derived through biotransformation during metabolism in the gut of bivalves. It is suggested that an oxidation of PTX2 occurs, leading to the formation of other PTX-group toxins, including PTX1, PTX3, and PTX6 PTX-group toxins have been shown to cause cell cycle arrest, cell death and apoptosis. The wide range (10-9 and 10-6 M) of effective concentrations of PTX-group toxins as well as the apparent resistance of some cell lines to the cytotoxic effect of PTX-group toxins indicate the existence of cell-specific factors affecting the sensitivity of biological systems to this group of natural compounds. Studies have confirmed that PTX2 induces apoptosis in several cell lines through multiple mechanisms, involving the perturbation of the cell cycle machinery, inhibition of mitotic separation and cytokinesis through the depolymerization of actin filaments. Oscillariolide and Phormidolide Oscillariolide is a halogenated macrolide isolated from a marine blue-green alga Oscillatoria sp. from Gokashowan-Bay, Mie Prefecture. It exhibits significant cytotoxic activity in the echinoderm egg assay. Phormidolide, a closely related macrolide was isolated from the extract of a laboratory culture of an Indonesian isolate of the cyanobacterium Phormidium sp. It displayed cytotoxicity towards drine shrimp with a LC50 of 1.5  µM. The characteristic features of both oscillariolide and phormidolide include a trisubstituted bridged THF macrolactone with a long polyhydroxy chain containing a unique terminal bromo diene. Structural elucidation revealed that the polyhydroxy side as well as THF ring of both compounds have same stereochemistry Chagosensine Chagosensine is a sixteen-membered chlorinated macrolide isolated from the methanolic chloroform extract of a bright yellow sponge Leucetta chagosensis usually found in the coral reefs of Red Sea, Aqaba Gulf (Israel). the extract of the Leucetta sp. sponge exhibited potent ability to inhibit the epidermal growth factor receptor signaling pathway. A new mechanism for the action of naamidine A and inhibition of tumor cells was shown.